1. Olmarker K, Rydevik B, Nordborg C. Autologous nucleus pulposus induces neurophysiologic and histologic changes in porcine cauda equina nerve roots. Spine (Phila Pa 1976) 1993;18:1425–1432. PMID:
8235812.
2. Olmarker K, Larsson K. Tumor necrosis factor alpha and nucleus-pulposus-induced nerve root injury. Spine (Phila Pa 1976) 1998;23:2538–2544. PMID:
9854752.
3. Toyone T, Takahashi K, Kitahara H, Yamagata M, Murakami M, Moriya H. Visualisation of symptomatic nerve roots. Prospective study of contrast-enhanced MRI in patients with lumbar disc herniation. J Bone Joint Surg Br 1993;75:529–533. PMID:
8331104.
4. Olmarker K, Storkson R, Berge OG. Pathogenesis of sciatic pain: a study of spontaneous behavior in rats exposed to experimental disc herniation. Spine (Phila Pa 1976) 2002;27:1312–1317. PMID:
12065980.
5. Olmarker K, Nutu M, Storkson R. Changes in spontaneous behavior in rats exposed to experimental disc herniation are blocked by selective TNF-alpha inhibition. Spine (Phila Pa 1976) 2003;28:1635–1641. PMID:
12897484.
6. Korhonen T, Karppinen J, Malmivaara A, et al. Efficacy of infliximab for disc herniation-induced sciatica: one-year follow-up. Spine (Phila Pa 1976) 2004;29:2115–2119. PMID:
15454701.
7. Korhonen T, Karppinen J, Paimela L, et al. The treatment of disc herniation-induced sciatica with infliximab: results of a randomized, controlled, 3-month follow-up study. Spine (Phila Pa 1976) 2005;30:2724–2728. PMID:
16371894.
8. Baeuerle PA, Baltimore D. NF-kappa B: ten years after. Cell 1996;87:13–20. PMID:
8858144.
9. Barnes PJ, Karin M. Nuclear factor-kappaB: a pivotal transcription factor in chronic inflammatory diseases. N Engl J Med 1997;336:1066–1071. PMID:
9091804.
10. Chan CF, Sun WZ, Lin JK, Lin-Shiau SY. Activation of transcription factors of nuclear factor kappa B, activator protein-1 and octamer factors in hyperalgesia. Eur J Pharmacol 2000;402:61–68. PMID:
10940358.
11. Ma W, Bisby MA. Increased activation of nuclear factor kappa B in rat lumbar dorsal root ganglion neurons following partial sciatic nerve injuries. Brain Res 1998;797:243–254. PMID:
9666140.
12. Novack DV, Teitelbaum SL. The osteoclast: friend or foe? Annu Rev Pathol 2008;3:457–484. PMID:
18039135.
13. Charatcharoenwitthaya N, Khosla S, Atkinson EJ, McCready LK, Riggs BL. Effect of blockade of TNF-alpha and interleukin-1 action on bone resorption in early postmenopausal women. J Bone Miner Res 2007;22:724–729. PMID:
17295604.
14. Eghbali-Fatourechi G, Khosla S, Sanyal A, Boyle WJ, Lacey DL, Riggs BL. Role of RANK ligand in mediating increased bone resorption in early postmenopausal women. J Clin Invest 2003;111:1221–1230. PMID:
12697741.
15. Feng X. Regulatory roles and molecular signaling of TNF family members in osteoclasts. Gene 2005;350:1–13. PMID:
15777737.
16. Teitelbaum SL. Bone resorption by osteoclasts. Science 2000;289:1504–1508. PMID:
10968780.
17. Boyce BF, Xing L. Functions of RANKL/RANK/OPG in bone modeling and remodeling. Arch Biochem Biophys 2008;473:139–146. PMID:
18395508.
18. Takasaki I, Andoh T, Shiraki K, Kuraishi Y. Allodynia and hyperalgesia induced by herpes simplex virus type-1 infection in mice. Pain 2000;86:95–101. PMID:
10779666.
19. Ohtori S, Takahashi K, Aoki Y, et al. Spinal neural cyclooxygenase-2 mediates pain caused in a rat model of lumbar disk herniation. J Pain 2004;5:385–391. PMID:
15501196.
20. Murata Y, Onda A, Rydevik B, Takahashi K, Olmarker K. Distribution and appearance of tumor necrosis factor-alpha in the dorsal root ganglion exposed to experimental disc herniation in rats. Spine (Phila Pa 1976) 2004;29:2235–2241. PMID:
15480134.
21. Obata K, Tsujino H, Yamanaka H, et al. Expression of neurotrophic factors in the dorsal root ganglion in a rat model of lumbar disc herniation. Pain 2002;99:121–132. PMID:
12237190.
22. Onda A, Murata Y, Rydevik B, Larsson K, Kikuchi S, Olmarker K. Infliximab attenuates immunoreactivity of brain-derived neurotrophic factor in a rat model of herniated nucleus pulposus. Spine (Phila Pa 1976) 2004;29:1857–1861. PMID:
15534405.
23. Olmarker K, Rydevik B. Selective inhibition of tumor necrosis factor-alpha prevents nucleus pulposus-induced thrombus formation, intraneural edema, and reduction of nerve conduction velocity: possible implications for future pharmacologic treatment strategies of sciatica. Spine (Phila Pa 1976) 2001;26:863–869. PMID:
11317106.
24. Ohtori S, Miyagi M, Eguchi Y, et al. Epidural administration of spinal nerves with the tumor necrosis factor-alpha inhibitor, etanercept, compared with dexamethasone for treatment of sciatica in patients with lumbar spinal stenosis: a prospective randomized study. Spine (Phila Pa 1976) 2012;37:439–444. PMID:
22020607.
25. Morishita R, Sugimoto T, Aoki M, et al. In vivo transfection of cis element "decoy" against nuclear factor-kappaB binding site prevents myocardial infarction. Nat Med 1997;3:894–899. PMID:
9256281.
26. Sakurai H, Shigemori N, Hisada Y, Ishizuka T, Kawashima K, Sugita T. Suppression of NF-kappa B and AP-1 activation by glucocorticoids in experimental glomerulonephritis in rats: molecular mechanisms of anti-nephritic action. Biochim Biophys Acta 1997;1362:252–262. PMID:
9540856.
27. Inoue G, Ochiai N, Ohtori S, et al. Injection of nuclear factor-kappa B decoy into the sciatic nerve suppresses mechanical allodynia and thermal hyperalgesia in a rat inflammatory pain model. Spine (Phila Pa 1976) 2006;31:2904–2908. PMID:
17139220.
28. Suzuki M, Inoue G, Gemba T, et al. Nuclear factor-kappa B decoy suppresses nerve injury and improves mechanical allodynia and thermal hyperalgesia in a rat lumbar disc herniation model. Eur Spine J 2009;18:1001–1007. PMID:
19308465.
29. Smith HS, Barkin RL. Painful boney metastases. Am J Ther 2014;21:106–130. PMID:
23344095.
30. Thomas D, Henshaw R, Skubitz K, et al. Denosumab in patients with giant-cell tumour of bone: an open-label, phase 2 study. Lancet Oncol 2010;11:275–280. PMID:
20149736.
31. Moen MD, Keam SJ. Denosumab: a review of its use in the treatment of postmenopausal osteoporosis. Drugs Aging 2011;28:63–82. PMID:
21174488.
32. Sakuma T, Kamoda H, Miyagi M, et al. Comparison of CatWalk analysis and von Frey testing for pain assessment in a rat model of nerve crush plus inflammation. Spine (Phila Pa 1976) 2013;38:E919–E924. PMID:
23615382.
33. Norimoto M, Ohtori S, Yamashita M, et al. Direct application of the TNF-alpha inhibitor, etanercept, does not affect CGRP expression and phenotypic change of DRG neurons following application of nucleus pulposus onto injured sciatic nerves in rats. Spine (Phila Pa 1976) 2008;33:2403–2408. PMID:
18824950.
34. Yamashita M, Ohtori S, Koshi T, et al. Tumor necrosis factor-alpha in the nucleus pulposus mediates radicular pain, but not increase of inflammatory peptide, associated with nerve damage in mice. Spine (Phila Pa 1976) 2008;33:1836–1842. PMID:
18670336.