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Clinical Study
Preoperative ligamentum flavum thickness as a predictor of the progression of postoperative hypertrophy at the cranial adjacent level after posterior lumbar interbody fusion: a retrospective observational study in Japan
Tatsuhisa Takekawa, Takeshi Oichi, Masanori Hashimoto, Masahiro Hirahata, Muneyoshi Fujita, Takahiro Inui, Keisuke Ishii, Satoshi Miyata, Hirotaka Kawano, Tomoaki Kitagawa
Received March 31, 2025  Accepted October 27, 2025  Published online March 17, 2026  
[Online first]
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β2-microglobulin amyloid deposition and the RAGE-related inflammation pathway in ligamentum flavum thickening among patients undergoing hemodialysis: a comparative cross-sectional study from Japan
Keisuke Ishikawa, Yutaka Yabe, Yoshito Onoda, Takahiro Onoki, Kohei Takahashi, Ko Hashimoto, Toshimi Aizawa
Received September 18, 2025  Accepted December 18, 2025  Published online March 17, 2026  
[Online first]
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Hybrid decompression-based surgical strategy for treating multilevel thoracic ossification of the ligamentum flavum: a retrospective study
Cong Nie, Kaiwen Chen, Shenyan Gu, Feizhou Lyu, Jianyuan Jiang, Xinlei Xia, Chaojun Zheng
Asian Spine J. 2025;19(1):74-84.   Published online February 24, 2025
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Basic Study
Transforming Growth Factor-β Induces Interleukin-6 Secretion from Human Ligamentum Flavum–Derived Cells through Partial Activation of p38 and p44/42 Mitogen-Activated Protein Kinases
Yuta Goto, Kenji Kato, Kiyoshi Yagi, Yohei Kawaguchi, Hiroki Yonezu, Tomoko Koshimae, Yuko Waguri-Nagaya, Hideki Murakami, Nobuyuki Suzuki
Asian Spine J. 2023;17(6):997-1003.   Published online November 10, 2023
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Clinical Study
Effects of Expression of Matrix Metalloproteinases and Discoidin Domain Receptors in Ligamentum Flavum Fibrosis in Patients with Degenerative Lumbar Canal Stenosis
Yusuf Mansur Torun, Emre Delen, Oğuzhan Doğanlar, Zeynep Banu Doğanlar, Özlem Delen, Metin Orakdöğen
Asian Spine J. 2023;17(1):194-202.   Published online September 27, 2022
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Basic Study
p38 Mitogen-Activated Protein Kinase Is Involved in Interleukin-6 Secretion from Human Ligamentum Flavum–Derived Cells Stimulated by Tumor Necrosis Factor-α
Kiyoshi Yagi, Yuta Goto, Kenji Kato, Nobuyuki Suzuki, Akira Kondo, Yuya Waseda, Jun Mizutani, Yohei Kawaguchi, Yuji Joyo, Yuko Waguri-Nagaya, Hideki Murakami
Asian Spine J. 2021;15(6):713-720.   Published online December 28, 2020
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Morphological Changes in the Ligamentum Flavum in Degenerative Lumbar Canal Stenosis: A Prospective, Comparative Study
Devanand Hulmani, Bhavuk Garg, Nishank Mehta, Asit Ranjan Mridha, Tapas Chandra Nag, Kamran Farooque
Asian Spine J. 2020;14(6):773-781.   Published online May 21, 2020
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Clinical Study
Surgical Results of Patients with Myelopathy due to Ossification of the Ligamentum Flavum with Ossification of the Posterior Longitudinal Ligament or a Vertebral Fracture at the Same Level of the Thoracic Spine: A Retrospective Comparative Study
Yuji Kasukawa, Naohisa Miyakoshi, Michio Hongo, Yoshinori Ishikawa, Daisuke Kudo, Ryota Kimura, Yuichi Ono, Jumpei Iida, Chiaki Sato, Yoichi Shimada
Asian Spine J. 2019;13(5):832-841.   Published online June 3, 2019
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Dorsal Spinal Ligamentum Flavum Thickening: A Magnetic Resonance Imaging Study
Amarnath Chelladurai, Suhasini Balasubramaniam, Sarenya Preyah Anbazhagan, Sathyan Gnanasihamani, Sukumar Ramaswami
Asian Spine J. 2018;12(1):47-51.   Published online February 7, 2018
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Change of Lumbar Ligamentum Flavum after Indirect Decompression Using Anterior Lumbar Interbody Fusion
Seiji Ohtori, Sumihisa Orita, Kazuyo Yamauchi, Yawara Eguchi, Yasuchika Aoki, Junichi Nakamura, Masayuki Miyagi, Miyako Suzuki, Gou Kubota, Kazuhide Inage, Takeshi Sainoh, Jun Sato, Kazuki Fujimoto, Yasuhiro Shiga, Koki Abe, Hiroto Kanamoto, Gen Inoue, Kazuhisa Takahashi, Takeo Furuya, Masao Koda
Asian Spine J. 2017;11(1):105-112.   Published online February 17, 2017
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Histopathological Analysis of Ligamentum Flavum in Lumbar Spinal Stenosis and Disc Herniation
Idiris Altun, Kasım Zafer Yüksel
Asian Spine J. 2017;11(1):71-74.   Published online February 17, 2017
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Analysis of the Relationship between Ligamentum Flavum Thickening and Lumbar Segmental Instability, Disc Degeneration, and Facet Joint Osteoarthritis in Lumbar Spinal Stenosis
Toyomi Yoshiiwa, Masashi Miyazaki, Naoki Notani, Toshinobu Ishihara, Masanori Kawano, Hiroshi Tsumura
Asian Spine J. 2016;10(6):1132-1140.   Published online December 8, 2016
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Analysis of the Relationship between Hypertrophy of the Ligamentum Flavum and Lumbar Segmental Motion with Aging Process
Toyomi Yoshiiwa, Masashi Miyazaki, Masanori Kawano, Shinichi Ikeda, Hiroshi Tsumura
Asian Spine J. 2016;10(3):528-535.   Published online June 16, 2016
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Thickness of the Ligamentum Flavum: Correlation with Age and Its Asymmetry-An Magnetic Resonance Imaging Study
Vrushali Subhash Kolte, Seema Khambatta, Medha Vijay Ambiye
Asian Spine J. 2015;9(2):245-253.   Published online April 15, 2015
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Case Report
Progressive Relapse of Ligamentum Flavum Ossification Following Decompressive Surgery
Kei Ando, Shiro Imagama, Zenya Ito, Kazuyoshi Kobayashi, Junichi Ukai, Akio Muramoto, Ryuichi Shinjo, Tomohiro Matsumoto, Hiroaki Nakashima, Naoki Ishiguro
Asian Spine J. 2014;8(6):835-839.   Published online December 17, 2014
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