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Girardo, Massè, Risitano, and Fusini: Long versus Short Segment Instrumentation in Osteoporotic Thoracolumbar Vertebral Fracture


Study Design

Retrospective comparative study.


This study aimed to compare clinical and radiological data and rate of mechanical complications in elderly patients treated with short segment (SSS) or long segment stabilization (LSS) for thoracolumbar junction osteoporotic vertebral fractures (OVFs).

Overview of Literature

A fervent debate is now focused on the treatment of OVF using SSS or LSS. High rate of complications is associated with pedicle screw fixation because of poor bone quality.


Patients over 65 years old with a T-score of <−2.5, affected by (T10–L2) vertebral fracture treated with LSS or SSS pedicle screw fixation, with at least 24 months of follow-up were evaluated. All patients were analyzed with conventional X-ray to evaluate bisegmental kyphotic angle (BKA) and clinically with Visual Analog Scale (VAS), Oswestry Disability Index (ODI), and rate of mechanical complications at 2, 6, 12, and 24 months. Data were expressed as mean±standard deviation. Student t-test was used to compare clinical scores between populations. Mann-Whitney U-test was used to analyze clinical and radiological variable, whereas Fisher’s exact test was used to identify differences in the rate of complications between groups.


A total of 37 patients met the inclusion criteria. Mean follow-up was 33.97±9.26 months. For both groups, ODI and VAS significantly decreased over time with good results (p<0.00001). At the final follow-up, no significant differences were found in terms of ODI and VAS. There was no difference in correction of BKA between groups; however, a significant difference was found in LSS group between pre- and postoperative BKA (p=0.046), whereas no difference was found in SSS group. A significant difference in the rate of mechanical complications was found between groups (p=0.011).


Both treatments showed good clinical and radiological results; however, LSS group showed better BKA correction and lower mechanical complications than SSS group.


Most of the elderly population are affected by osteoporosis, presenting as a major health burden owing to increased risk of fracture and subsequent disability or related death. Low bone density affects bone strength, particularly in the vertebral body [1,2]. Surgical treatment for osteoporotic vertebral fracture (OVF) is still challenging for spine surgeons. The literature reports several approaches to treatment, but there is no current consensus on a standard technique [3-7]. Compared with younger population, high rate of complications is associated with pedicle screw fixation because of poor bone quality such as loosening, pullout, or screw migration [8].
Improvement of fixation technique and new pedicle screw shape could help spine surgeons in the treatment of challenging cases [5,9]. However, despite these features, the risk of treatment failure is still high [10,11]. Currently, a fervent debate is focused on the treatment for OVF using short segment (SSS) or long segment stabilization (LSS). Some surgeons prefer to save motion of adjacent segments, hence choosing SSS, whereas other surgeons opt to obtain a more stable construct with LSS but sacrificing some segment of motion [12,13].
This study aimed to evaluate and compare clinical and radiological data and rate of mechanical complications in patients treated with SSS or LSS for OVF of the thoracolumbar junction.

Materials and Methods

1. Study design

Clinical and radiological data of patients treated in our institution using long or short segment pedicle screw fixation for osteoporotic fracture of the thoracolumbar spine (T10–L2) were collected and reviewed. All patients were evaluated using radiological examination with conventional X-ray and clinically with Visual Analog Scale (VAS) and Oswestry Disability Index (ODI) at 2, 6, 12, and 24 months. The need for surgical revision and complications were also recorded.

2. Selection and description of participants

Between January 2015 and December 2016, 137 consecutive patients affected by thoracolumbar vertebral fracture were admitted in our Orthopaedic and Trauma Centre, Azienda Ospedaliero Universitaria Città della Salute e della Scienza di Torino, Turin. Their records were identified using a retroactive revision of our database using the TrakCare program (InterSystems Corp., Cambridge, MA, USA).
We included patients over 65 years of age with a T-score of <−2.5, affected by T10–L2 vertebral fractures treated in our institution using SSS (one level above and under the fracture with intermediate screws in the affected vertebra) or LSS (two level above and below the affected vertebra, with or without intermediate screws) with or without polymethylmethacrylate (PMMA) augmentation. All patients were affected by osteoporotic fractures (OF) 3, OF 4, or OF 5 types of vertebral fracture according to the German Society for Orthopaedics and Trauma (DGOU) classification [14] and an OF classification-based scoring system >6.
The exclusion criteria were as follows: polytrauma, inflammatory diseases such as ankylosing spondylitis and rheumatoid arthritis, history of major surgery of the thoracolumbar spine (i.e., arthrodesis or with a combined approach [posterior+anterior]) or treated with vertebroplasty (VP) and kyphoplasty (KP) of the index vertebra, incomplete radiological or clinical data, or less than 24 months of follow-up.

3. Treatments

All patients underwent a posterior stabilization with pedicle screws using an open approach with a freehand technique under general anesthesia. Intermediate short-segment pedicle screws in the fractured vertebra were positioned according to pedicle integrity. In case of single pedicle fracture, screws were positioned asymmetrically, whereas no screws were positioned in case of bilateral pedicle fracture. Screw positioning was checked intraoperatively with fluoroscopic guidance. After surgery, all patients were free to move without support or corset. Generally, fractures with small fragmentation and comminuted fragments with acceptable kyphosis were treated with SSS (Figs. 1, 2) using intermediate pedicle screws according to pedicle integrity. In case of great fragmentation and comminuted fragments and segment kyphosis of >20°, an LSS was preferred (Fig. 3). Usually, stand-alone VP or KP can be used to successfully treat wedge fractures (AO A1 or OF 2) or incomplete burst fractures (AO A3 or OF 3) after 3 weeks of unsuccessful conservative treatment because of persistent pain [15,16]. In case of major posterior wall displacement or interruption, pedicle screws are preferable instead of VP or KP owing to risk of iatrogenic narrowing of the spinal canal [15].
Solid pedicle screws or augmented cannulated pedicle screws were used in all cases. No cannulated pedicle screws without PMMA augmentation were used, based on the results of our previous work [4].

4. Radiological assessment

An independent radiologist, not involved in the study, evaluated the radiological data of all patients: thoracolumbar anteroposterior and lateral X-rays at 40 days, and 6, 12, and 24 months. Fractures were classified according to OF classification system [17]. Bisegmental kyphotic angle (BKA) on conventional X-ray was evaluated before treatment and at each follow-up.

5. Measurements

During follow-up, patients were clinically evaluated with VAS and ODI. All complications were recorded; proximal junctional kyphosis (PJK), implant loosening, pullout, or screw breakage were all considered as mechanical complications.
The study was conducted according to the Declaration of Helsinki and its later amendments. Ethical approval was obtained from Inter-Hospital Ethical Committee (no., 14/0006482). All patients provide written informed consent prior participation to the study.

6. Statistical analysis

Collected data are expressed as mean±standard deviation. Student t-test was used to compare clinical scores between populations. Mann-Whitney U-test was used to analyze clinical and radiological variables, whereas Fisher’s exact test was used to identify differences in the rate of complications between short segment group and long segment group or between solid pedicle screws or augmented cannulated pedicle screws in each group. A p<0.05 was considered statistically significant. Stata ver. 13.0 software (Stata Corp., College Station, TX, USA) was used for statistical analysis.


A total of 37 patients (22 females and 15 males) met the inclusion criteria. Mean follow-up was 33.97±9.26 months. Demographic data and fracture types are presented in Table 1. Both groups were similar preoperatively.
For both groups, ODI and VAS significantly decreased over time with good results (p<0.00001). At the final follow-up, no significant differences were found in term of ODI (p=0.906) and VAS (p=0.853). Statistical analysis showed no difference in correction of BKA between groups (p=0.785); however, a significant difference was found he in LSS group between pre- and postoperative BKA (p=0.046), whereas the same difference was not found in the SSS group (p=0.269). All complications are presented in Table 2. One mechanical complication was reported for the LSS group (one PJK), whereas six mechanical complications were reported for the SSS group (three pullout, one PJK, two loosening). A significant difference was found between groups for mechanical complications (p=0.011).
In the subgroup analysis, 12 patients were treated with solid screws and 10 patients with augmented cannulated pedicle screws in the LSS group, whereas nine patients were treated with solid screws and six with augmented cannulated pedicle screws in the SSS group. Patients with PJK in the LSS group were treated with solid screws, whereas those in the SSS group were treated with cannulated augmented pedicle screws. All patients with other mechanical complications in the SSS group (pullout and screw loosening) were treated with solid screws. No difference was found in global mechanical failure between solid or augmented cannulated pedicle screws (p=0.11). For screw pullout and loosening, no difference was observed in the LSS group (p=1), whereas a significant statistical difference was found in the SSS group (p<0.044).


Choosing between SSS and LSS is one of the major dilemmas among spine surgeons. Both types of fixation have some advantages among the other: LSS provides good implant and fracture stability, whereas SSS allows surgeons to save some segment of motion to preserve function of adjacent segments and save some operating time and blood loss [18,19].
In a recent meta-analysis, Aly found no difference in terms of radiological and functional outcome, neurologic improvement, and rate of implant failure. However, these results were based on the observation of traumatic fracture in young patients and not in the osteoporotic population [20]. Moreover, according to our results, the analysis of kyphotic correction made by Assuncao Filho et al. [21] indicated poorer corrections for SSS immediately after surgery and a greater loss of this correction in the long-term follow-up. In our comparative study, we did not find a worse loss of kyphotic correction over time; in fact, after 3 months from surgery, kyphotic deformity tended to remain stable over time. This result could be associated to the use of intermediate screw at the fracture level, which improved stability of the construct [22,23], allowing surgeons to save some segments of motion and achieving maintenance of sagittal alignment similar to an LSS [24]. On the other hand, LSS still remains a valuable choice in highly unstable fractures, where a longer stabilization provides optimal stability [22].
Based on these premises, OVF should be considered as potentially highly unstable fractures, owing to poor bone quality and strength [25]. In cases with very fragmented vertebral body collapse, posterior LSS offers better clinical and radiological outcomes with lower incidence of mechanical complications [26]. However, LSS exposes patients to longer operating time and more blood loss along with a higher risk of implant infection [27].
The recent finite element analysis performed by Wu et al. [28] analyzed the behavior of LSS and SSS for severe thoracolumbar fracture suggested that LSS is a better choice in osteoporotic patients, similar to our results. LSS provides the greatest mechanical stiffness and can reduce further segmental collapse. However, the authors also reported some limitations to their experiment such as the analysis of a single-level injury, the assumption that the vertebral body is homogeneous, no interaction with muscle contraction and stabilization function, and data that did not take into consideration individual physiological differences [28].
Following the DGOU recommendation, an SSS is indicated for type 3 OVF, whereas an LSS is recommended for types 4 and 5. In our retrospective study, our treatment choice and DGOU recommendation were in agreement in most of cases, except for three patients with OF 4 fracture treated with SSS [14]. Two of these three patients had mechanical complications. However, in the other case, we chose to perform cement augmentation and no mechanical complication was recorded. These data were insufficient to gain any definitive conclusion, but they suggest that even in case of an inadequate treatment the use of augmentation technique could help surgeons in lowering mechanical complications, especially in OF 4 fracture that involves different shapes of fracture [16]. Nevertheless, it must be noted that SSS with augmentation did not result in expected biomechanical benefits and lengthening of dorsal instrumentation resulted in higher resistance to fatigue test and pullout in biomechanical test of cadaveric specimens [29].
To the best of our knowledge, this is the first study analyzing clinical and radiological outcomes of OVF in elderly patients; other studies in the literature were focused on whole vertebral fracture without distinction between young and elderly population.
This study has some limitations. Some are intrinsic to the study design, such as the lack of randomization and the retrospective nature. The decision of performing LSS or SSS has been entrusted to surgeon’s own experience and types of fracture, without following DGOU recommendations, because all cases were treated before the development of the classification [16].
Moreover, only a minimum follow-up time was set with 24–48 months. Moreover, the small number of patients and the lack of a priori sample size calculation could be sources of potential bias. No systematic investigation of global spine alignment was performed. This could be considered a source of bias because misalignment of the spine and alterations of spinopelvic parameters could influence global outcomes, as described in an analysis in young and elderly patients [30,31].

Conflicts of interest

No potential conflict of interest relevant to this article was reported.

Fig. 1.
Preoperative computed tomography scan with evidence of involvement of posterior wall in sagittal (A) and axial view (B) and postoperative L1 vertebral fracture X-ray (C) of a 78-year-old male patient treated with short segment instrumentation with short screw in affected vertebra without augmentation (arrow).
Fig. 2.
Preoperative computed tomography scan evaluation in axial (A) and sagittal (B) view of a 76-year-old female patient with L1 vertebral fracture (arrow). (C) Postoperative X-ray of fracture treated with short segment fixation without augmentation.
Fig. 3.
(A, B) Postoperative X-ray in anteroposterior and lateral view of L1 vertebral fracture of a 66-year-old female patient treated with long segment fixation (two level above and below affected vertebrae) with polymethylmeth polymethylmethacrylate without intermediate screw.
Table 1.
Main demographic characteristics of patients included in the study with OF classification distribution
Characteristic Value
Mean age (yr) 70.38±5.45
 Female 22
 Male 15
Long segment stabilization group
 Male 7
 Female 15
 OF classification 18 OF4, 4 OF5
Short segment stabilization group
 Male 8
 Female 7
 OF classification 12 OF3, 3 OF4
Total 37
 OF classification 12 OF3, 21 OF4, 4 OF5
Mechanism of injury
 No relevant traumaa) 9
 Minor traumab) 15
 Fall from heightc) 8
 Other moderate energy traumad) 5

Values are presented as mean±standard deviation or number.

OF, osteoporotic fractures.

a) No relevant trauma connected to vertebral injury, i.e., twisting, coughing, sneezing, etc.

b) Fall from standing, seated position or from bed.

c) Fall from less than 1 m height.

d) Car accident at low speed, pedestrian hit at extremely low speed, etc.

Table 2.
Complications overview of patients included in the study and treated with SSS or LSS
Variable LSS SSS p-value Global p-value
Wound dehiscence 2 2 1 1
Leakage 3 1 0.633
Pulmonary embolism 1 - 1
Transitory paresthesia - 1 0.41
Proximal junctional kyphosis 1 1 1 0.011
Loosening - 2 0.16
Pull out - 3 0.059

SSS, short segment stabilization; LSS, long segment stabilization.


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