Effects of Central Sensitivity Syndrome and Psychological Factors on the Clinical Features of Patients with Cervical Degenerative Disease: A Cross-Sectional Study

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Asian Spine J. 2021;15(4):464-471

Publication date (electronic) : 2020 November 9

doi : https://doi.org/10.31616/asj.2020.0177

Yu Kondo¹, Takahiro Miki^,1, Daisuke Higuchi², Tsuneo Takebayashi³

¹Department of Rehabilitation, Sapporo Maruyama Orthopedic Hospital, Sapporo, Japan

²Department of Physical Therapy, Takasaki University of Health and Welfare, Takasaki, Japan

³Department of Orthopaedic Surgery, Sapporo Maruyama Orthopedic Hospital, Sapporo, Japan

Corresponding author: Takahiro Miki Department of Rehabilitation, Sapporo Maruyama Orthopedic Hospital, N7-W27, Chuo-ku, Sapporo, Hokkaido 060-0007, Japan Tel: +81-11-612-1133, Fax: +81-11-612-8151, E-mail: tkhr.mk@gmail.com

Received 2020 April 18; Revised 2020 July 1; Accepted 2020 July 4.

Abstract

Introduction

Cervical diseases are a class of common musculoskeletal disorders that are widely recognized as a major health problem [1]. Many people experience recurrent or chronic symptoms, resulting in increased health care costs and social loss [2]. Among the cervical diseases, cervical degenerative disease (CDD) affects the spinal cord and nerve roots, sometimes causing neuropathic pain. Although the efficacy of conservative therapy has been reported for mild cases [3], surgical treatment is often required for severe or progressive cases of CDD. However, even if surgery is performed properly and the pressure on the nerve is released, postoperative residual pain is often experienced [4]. The pathology of CDD is complex, and the underlying mechanisms that contribute to pain management and recovery are incompletely understood.

Recently, central sensitization (CS) has been suggested as a condition of chronic pain. The International Association for the Study of Pain defines CS as increased responsiveness of nociceptive neurons in the central nervous system to their normal or subthreshold afferent input [5]. Multiple factors, including psychological factors, may cause dysregulation of bottom-up or top-down modulation and cause CS [6]. Well-known psychological factors involved in CS include pain catastrophizing, depression, fear, anxiety, stress, and inadequate knowledge of the respective disease. In support of this, previous studies have reported that negative emotion impairs the descending inhibitory pathways [7].

Many conditions of chronic pain, such as low back pain [8] as well as neck and shoulder pain [9] are characterized by hypersensitivity induced by CS. Yunus [10] proposed the idea of an overlapping and similar group of syndromes bound by the common mechanisms of CS, called central sensitivity syndromes (CSS). Recent investigations have shown that CSS patients may also have the clinical features in lumbar disease [8]. Moreover, CSS patients are reported to have significantly lower values for catastrophic thinking, fear of exercise, and sleep effects than controls for patients with neck and shoulder pain [9].

A previous study has reported the effects of psychological factors in the development of CDD [11-13]. However, to our knowledge, no studies have focused on the influence of CSS in terms of the development of CDD, and the precise effects of CSS are unclear. CSS may affect the clinical symptoms of CDD. The present study aimed to investigate the effects of CSS and the psychological factors on the clinical features of CDD patients.

Materials and Methods

4. Measures

1) Numerical Rating Scale for neck pain intensity

Pain intensity was measured using the 11-point NRS to determine average neck pain intensity on the day of the evaluation. A score of 0 indicates no pain, and a score of 10 indicates the worst imaginable pain.

2) Neck Disability Index

Disability was measured using the Japanese version of the NDI [16]. The NDI includes 10 items, scored from 0 to 5. The total score is converted to a percentage, with a higher total score indicating greater disability. Previous studies have demonstrated the high internal consistency (Cronbach’s α of all items=0.89) of the Japanese version of the NDI [16].

3) EuroQol 5-Dimensions

We measured the HRQOL using the Japanese version of the EQ-5D [17]. The EQ-5D consists of 5 dimensions relating to the state of health: mobility, self-care, usual activities, pain/discomfort, and anxiety/depression. A higher score indicates a better quality of life, with a maximum score of 1 [18].

4) Central Sensitization Inventory

The Japanese version of the CSI was used to assess CSS [19]. The CSI includes 25 items, scored from 0 to 4 (Table 1) [14]. A higher total score indicates more severe CSS, with a total score of 40 being the cutoff [14]. Previous studies have demonstrated this system to exhibit good criterion validity, construct validity, and test-retest reliability (intra-class correlation coefficient=0.85) [19].

Table 1.

Central Sensitization Inventory [14]

5) Pain Catastrophizing Scale

Pain catastrophizing was measured using the Japanese version of the PCS that includes 13 items, with scores ranging from 0 to 4 [20]. A higher total score indicates a greater degree of pain catastrophizing, and a total score of 30 is the cutoff point for clinically relevant level of catastrophizing [21]. Previous studies have demonstrated the construct validity and high internal consistency (Cronbach’s α of all items=0.89) of the Japanese version of the PCS [20].

6) Tampa Scale for Kinesiophobia

Kinesiophobia was measured using the Japanese version of the TSK [22]. The TSK includes 17 items, scored from 1 to 4. A higher total score indicates greater kinesiophobia, and a total score of 37 is the cutoff point that relates to strong kinesiophobia [22]. Previous studies have demonstrated the concurrent validity and high internal consistency (Cronbach’s α of all items=0.85) of the Japanese version of the TSK [22].

7) Hospital Anxiety and Depression Scale

Anxiety or depression was measured using the Japanese version of the HADS [23]. The HADS includes 14 items, with scores ranging from 0 to 3. Odd number items are for depression, and the even number items are for anxiety. A higher total score indicates greater anxiety or depression. In each subscale of anxiety or depression, a total score of 8 is the cutoff point for the identification of suspicious cases for depression and anxiety [23]. Previous studies have demonstrated the construct validity of the Japanese version of the HADS [23].

Results

1. Participant characteristics

Seventy-two patients with CDD were included based on the aforementioned inclusion criteria. Of the study population, 6.9% (5/72) had incomplete data, representing 2% of the 86 questions (121/6,002). These missing values were complemented with the multiple imputation method. In total, the data of 72 patients were analyzed. Of these, 42 patients were treated for cervical spondylotic myelopathy, 18 for cervical spondylotic radiculopathy, four for cervical disc herniation, and seven for ossification of the posterior longitudinal ligamentum. The characteristics of the study population are summarized in Table 2.

Table 2.

Characteristics of the study population (n=72)

2. Correlation analysis

Table 3 presents the correlation between CSI and PROMs for psychological factors and clinical features. We found that CSI was significantly and moderately correlated with NRS (r=0.50, p<0.01), NDI (r=0.64, p<0.01), and EQ-5D (r=−0.55, p<0.01). Both TSK and HADS were significantly correlated with some clinical features.

Table 3.

Correlations between clinical features and evaluated variables

3. Multiple regression analyses

Tables 4–6 present the results of multiple regression models with NRS, NDI, and EQ-5D as the dependent variables, respectively. The constructed model for the identification of NRS, NDI, and EQ-5D significantly fits the overall data (R²=0.25, adjusted R²=0.24, p<0.01; R²=0.40, adjusted R²=0.40, p<0.01; and R²=0.30, adjusted R²=0.29, p<0.01), respectively. CSI has a significant effect on NRS (β, 0.50; 95% CI, 0.29 to 0.71), NDI (β, 0.64; 95% CI, 0.45 to 0.82), and EQ-5D (β, −0.55; 95% CI, −0.75 to −0.35). The PROMs for psychological factors did not significantly affect the clinical features. There were no associations with multicollinearity (variance inflation factor <3.0), indicating that the results were reliable.

Table 4.

Results of multiple regression analysis with pain intensity as the dependent variable

Table 5.

Results of multiple regression analysis with disability as the dependent variable

Table 6.

Results of multiple regression analysis with health-related quality of life as the dependent variable

Discussion

This study revealed that CSI is a significant identifying factor for the clinical features, suggesting that CSS has a significant effect on the clinical features of CDD patients.

Previous studies have investigated the effects of CSS in lumbar disease; Bennett et al. [25] found that preoperative CSI is associated with reduced HRQOL and increased length of hospital stay after lumbar spinal fusion. In particular, for every 10-point increase in the CSI score, the length of hospital stay increased by 6.4%. Neblett et al. [8] reported that the CSI score at the time of admission for chronic spinal pain is associated with pain intensity and that interdisciplinary biopsychosocial treatment can significantly improve the CSI score.

Multiple regression analysis in the present study revealed that the CSI score was significant for identifying the pain intensity, disability, and HRQOL. Therefore, after controlling for other confounding factors, we suggest that more severe CSS is associated with more severe clinical features in CDD patients. Our conclusions are consistent with previous studies in terms of the effects of CSS on the clinical features of patients with lumbar disease [8,25].

The present analysis of the correlations between psychological factors and clinical features revealed that TSK and HADS were significantly correlated with some clinical features. However, these factors did not affect the clinical features when CSI and psychological factors were used simultaneously as independent variables in multiple regression analysis.

Previous studies have analyzed the effects of psychological factors on the clinical features of CDD patients. In their evaluation of depression using the Patient Health Questionnaire-9 following posterior cervical fusion, Alvin et al. [11] demonstrated, through multiple linear and logistic regression analyses, that more severe preoperative depression is associated with a worse EQ-5D score at 1 year postoperatively. Archer et al. [12] reported that the preoperative symptoms of depression predict increased pain interference and disability and decreased HRQOL at 6 months after the surgery for lumbar or cervical degenerative conditions. In contrast, Doi et al. [13] found that cervical spinal fusion is associated with significant improvement of HRQOL and sufficient levels of satisfaction after the surgery, regardless of the presence of preoperative depression or anxiety in CDD patients.

Thus far, there is no consensus of the influence of psychological factors on CDD development. The results of previous studies about the effects of psychological factors in CDD patients do not account for CSS. Several studies have reported that pain intensity could be associated with the CSI score as well as psychological factors [8,26]. Shigetoh et al. [27] found that CS mediates the relationship between pain intensity and psychological factors including depression. Van Wilgen et al. [26] demonstrated the convergent validity of CSI score by evaluating the clinical features of CS and psychological factors. In addition to primary symptoms associated with CSS, the CSI also briefly assesses psychological factors, including anxiety, depression, and panic disorder. To our knowledge, no previous studies have simultaneously investigated the effects of CSS and psychosocial factors in CDD patients. The present study suggests that CSI may reflect clinical features to a better degree than PROMs for psychological factors.

For the clinical implication, treatment of CSS should focus on multidisciplinary biopsychosocial treatment and medications, such as dual reuptake inhibitors [8,14]. A high CSI score should not preclude surgical treatment; however, clinicians should select their patients carefully and follow different treatment policies as per need. Our findings highlight the utility of the CSI score for identifying the severity of clinical features among such patients. The addition of CSI that comprehensively assesses psychological factors has the potential to help diagnose patients with CDD and develop an appropriate treatment plan.

The present study has certain limitations that need to be acknowledged. The first is that CSS was evaluated using the CSI score; the diagnosis of CSS could not be established using more objective evaluations. In fact, the PROM score might have been affected by age, cognition, and cultural aspects, such as the fact that the population was Japanese. Quantitative Sensory Testing (QST) has been used to assess CSS in order to quantify somatosensory function [28]. Although a correlation between clinical symptoms measured using QST and CSS has been reported [29], QST is often thought of as a direct indicator of CSS. Therefore, it may be more reliable to measure QST in this study. The second limitation is the relatively small sample size. Total 72 participants were selected; however, the number of participants was insufficient. Further large studies are needed in order to confirm our findings. Finally, this was a cross-sectional study; therefore, a causal relationship between CSI and clinical features cannot be confirmed. Prospective studies are required to validate the CSI score as a screening tool for cervical spine surgery. For example, it has been reported that preoperative CSI scores in people with lumbar disease had prolonged discharge and lower HRQOL [25]. Therefore, it is necessary to examine how the preoperative CSI scores affect postoperative outcomes in cervical disease.

Conclusions

This study investigated the effects of CSS and psychological factors on the clinical features of CDD patients with CDD. We found that CSI can help identify clinical features, suggesting that CSS affects pain intensity, disability and HRQOL of CDD patients. Our findings may facilitate clinical decision making because they highlight the importance of evaluating CSI in the clinic for identifying the severity of clinical features of CDD patients and plan appropriate management strategies.

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