Comparison of Unilateral Biportal Endoscopy Decompression and Microscopic Decompression Effectiveness in Lumbar Spinal Stenosis Treatment: A Systematic Review and Meta-analysis

Li Junjie; Yin Jiheng; Liu Jun; Lin haixiong; Yuan Haifeng

doi:10.31616/asj.2021.0527

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Junjie, Jiheng, Jun, haixiong, and Haifeng: Comparison of Unilateral Biportal Endoscopy Decompression and Microscopic Decompression Effectiveness in Lumbar Spinal Stenosis Treatment: A Systematic Review and Meta-analysis

Review Article

Asian Spine Journal 2023;17(2):418-430.

Online first: February 6, 2023

DOI: https://doi.org/10.31616/asj.2021.0527

Comparison of Unilateral Biportal Endoscopy Decompression and Microscopic Decompression Effectiveness in Lumbar Spinal Stenosis Treatment: A Systematic Review and Meta-analysis

Li Junjie¹

, Yin Jiheng¹

, Liu Jun²

, Lin haixiong^1,³

, Yuan Haifeng⁴

¹Department of Orthopaedics, Ningxia Traditional Chinese Medicine Hospital and Chinese Medicine Research Center, Yinchuan, People’s Republic of China

²Department of Orthopaedics, Yinchuan Guolong Hospital, Yinchuan, People’s Republic of China

³Institute for Tissue Engineering and Regenerative Medicine, The Chinese University of Hong Kong, Hong Kong SAR, People’s Republic of China

⁴Department of Spine Orthopaedics, General Hospital of Ningxia Medical University, Yinchuan, People’s Republic of China

Corresponding author: Yuan Haifeng, General Hospital of Ningxia Medical University, No. 804 Shengli Street, Xingqing District, Yinchuan City, Ningxia Hui Autonomous Region, People’s Republic of China,
Tel: +86-18709571510, Fax: +86-0951-4091488, E-mail: doctor_lingdu@126.com

Received February 4, 2022 Revised May 20, 2022 Accepted June 7, 2022

This is an Open Access article distributed under the terms of the Creative Commons Attribution Non-Commercial License (http://creativecommons.org/licenses/by-nc/4.0/) which permits unrestricted non-commercial use, distribution, and reproduction in any medium, provided the original work is properly cited.

Abstract

This study aimed to compare the safety and effectiveness between unilateral biportal endoscopy (UBE) technique and microscopic decompression (MD) technique in lumbar spinal stenosis treatment. PubMed, Cochrane Library, Embase, Web of Science, China National Knowledge Infrastructure, and other databases were used to conduct extensive literature searches. RevMan ver. 5.3 software was used for the statistical analysis. Eleven studies were included with 930 patients, including 449 patients in the UBE group and 521 in the MD group. Both techniques revealed similar operative times at −1.77 minutes (95% confidence interval [CI], −7.59 to 4.05 minutes; p=0.55), the postoperative dural expansion area at −1.27 (95% CI, −19.30 to 16.77; p=0.89), the postoperative complications at 0.76 (95% CI, 0.47 to 1.22; p=0.26), the preoperative Visual Analog Scale (VAS) for leg pain, and the last follow-up (>12 months) VAS for leg pain at −0.04 (95% CI, −0.14 to 0.06; p=0.47), the preoperative Oswestry Disability Index (ODI), and the last follow-up (>12 months) ODI scores at −0.18 (95% CI, −0.76 to 0.40; p=0.54), and patient satisfaction (the modified MacNab score) at 1.15 (95% CI, 0.54 to 2.42; p=0.72). However, intraoperative bleeding was lower following the UBE technique at −52.78 mL (95% CI, −93.47 to −12.08 mL; p=0.01) and was shorter following the UBE technique at −3.06 (95% CI, −3.84 to −2.28; p<0.01). UBE and MD technology have no significant differences in efficacy or safety in the treatment of patients with lumbar spinal stenosis based on this meta-analysis. However, the UBE technique has less intraoperative bleeding and a shorter hospital stay. It has a slight advantage and is a better surgical option than the MD technique. It can be an alternative minimally invasive spinal surgery method.

Keywords: Unilateral biportal endoscopy; Biportal endoscopic spinal surgery; Endoscopic spinal decompression; Microscopic decompression; Minimally invasive spine surgery; Lumbar canal stenosis; Systematic review and meta-analysis

Introduction

Lumbar spinal stenosis is a degenerative disease commonly seen in elderly individuals. Surgical intervention is commonly required for patients who fail conservative treatment. Minimally invasive spine surgery has become a research hotspot in the treatment of spinal degenerative diseases with the rapid development of technology in recent years [1]. An increasing number of minimally invasive surgery techniques and results have been reported. Microscopic decompression (MD) unilateral laminectomy and unilateral laminectomy for bilateral decompression are considered to be the routine methods of standard minimally invasive surgery for lumbar spinal stenosis [2–4]. However, MD technology has some shortcomings, including poor visual field, difficult instrument operation, possible insufficient decompression, and longer operation time than other minimally invasive procedures [5–10]. The prevalence of unilateral biportal endoscopic (UBE) technology, also known as biportal endoscopic spinal surgery (BESS), has made up for some of the deficiencies of MD technology. It uses two channels on the same side of the spine: one observation channel and one operation channel. It uses saline to continuously irrigate the deltoid space of the multifidus muscle to create a clear surgical field of vision. It can be completed with power drills and conventional open surgical instruments. Total spinal canal decompression surgery can be performed under a microscope [11]. UBE/BESS technology has been successfully applied to the treatment of degenerative spinal diseases and has been rapidly “revised” in recent years due to its wide field of vision, the large operating angle of the instruments, and the same operating habits as traditional open surgery [12,13]. However, the safety and effectiveness of the emerging UBE/BESS technology in the treatment of lumbar spinal stenosis remain controversial [14–17].

For the first time, this study compared the area of dural sac expansion, the change in C-reactive protein (CRP) value, and the change in patient satisfaction (the modified MacNab score) with lumbar spinal stenosis after two surgical technology treatments compared with the previous meta-analysis [2,18]. The research sample size was increased, and the persuasiveness and credibility of the results were improved.

Methodology

PubMed, Web of Science, Embase and Cochrane Library, China National Knowledge Infrastructure, WanFang, and VIP databases were used to conduct a comprehensive search. Using subject terms, free words, and a combination of the two, the following search terms were used: “unilateral biportal endoscopy,” “biportal endoscopic spinal surgery,” “biportal endoscopic,” “spine endoscopy,” “microscopic decompression,” “minimally invasive spine,” and “lumbar canal stenosis.” The Boolean operations “AND” and “OR” were used to search. English or Chinese was the language used, and the search time was from the establishment of the database to July 30, 2021. This study did not require Institutional Review Board approval and/or informed consent.

1. Inclusion and exclusion criteria

Studies were selected that satisfied the following inclusion criteria: (1) compared the clinical results and laminectomy and decompression efficacy alone in patients with lumbar spinal stenosis treated with UBE and MD techniques. (2) The comparison outcome had at least one of the following: clinical, surgical, and imaging-related parameters (pre- and postoperative Visual Analog Scale [VAS] for leg pain, Oswestry Disability Index [ODI] score, surgery time, blood loss, complications, hospital stay, etc.). (3) The full text could be obtained; complete and useful data could be extracted. The measurement data were expressed as averages±standard deviation. Excluded studies were as follows: (1) case reports, review articles, published abstracts, studies involving fewer than 10 patients, and duplicate data and (2) articles with unavailable access to the full text.

2. Study selection

The research object was determined by reading the title and literature abstract according to two independent authors (L.J. and Y.J.). The full text was searched if a decision could not be made. Disagreements were resolved through consensus and discussion with a third party (Y.H.). A bias risk assessment was performed. The reason for nonconformity or exclusion of the study was recorded and described.

3. Data extraction

Relevant data were extracted by two independent investigators after intensive reading of the full text, mainly including the name of the first author, publication year, study type, sample size, average age, complications, outcome indicators, and follow-up time. Data were statistically tabulated. The third researcher participated in the discussion and made a decision through consultation if there was a disagreement. If necessary, the authors of the literature were contacted to clarify relevant information of the research.

4. Quality assessment

For randomized controlled trials, the evaluation quality refers to the standards recommended by the Cochrane system [19]. For nonrandomized controlled trials, the quality of the literature was evaluated according to the Risk of Bias Assessment of Non-randomized Studies (RoBANS) guidelines [20]. If the two investigators disagreed, they discussed and resolved the point of disagreement. If there were still differences, the third party joined the discussion and helped settle the disagreement.

5. Statistical analysis

Review Manager software ver. 5.3 (the Cochrane Collaboration, London, UK) was used to perform statistical analysis and the results are represented by forest diagrams. The heterogeneity test was performed when the data were merged. The fixed-effects model was adopted if there was no obvious heterogeneity between the data (I²≤50%). The heterogeneity was analyzed if there was heterogeneity (I²>50%). A random-effects model was used if the heterogeneity could not be removed qualitatively. A funnel chart was used to analyze the publication bias of the literature if there were more than 10 studies included in a certain outcome index. The odds ratio was calculated for the binary variables and the relative risk was used as the effect scale. The mean difference was used for continuous variables. Different evaluation scales and large errors exist between the individual measured values and standardized mean difference combined statistics were selected if the numerical units are different. A p<0.05 indicates that the difference between the two groups is significant.

Results

1. Literature search

A total of 386 related documents were obtained through a preliminary search. Eleven articles were ultimately included [15,21–30] (Fig. 1, Table 1) after rescreening by eliminating duplicate documents, reading titles and abstracts, and full text. There were 10 articles in English [15,21–28,30] and one article in Chinese [29]. There were 930 patients, including 449 patients in UBE and 521 in MD.

2. Study characteristics and risk assessment

Only two of the included studies were randomized controlled trials [26,27] and the overall quality was moderate to high, according to the Cochrane system (Fig. 2). The remaining nine studies were nonrandomized controlled trials [15,21–25,28–30]. Risk assessment was conducted according to the RoBANS guidelines. Each study had a certain degree of bias. Table 2 shows the specific evaluation results.

3. Operation time

Seven studies were included to evaluate the operation time of the two surgery types with 291 patients in the UBE group and 283 in the MD group [15,22–27]. There was statistical heterogeneity between the study groups (I²=94%). Thus, the random-effects model was used for statistical analysis and was grouped according to the different study types. There was no significant difference between the two (mean difference, −1.77; 95% CI, −7.59 to 4.05; p=0.55]. Therefore, in terms of operation time, a difference could not be identified between the two surgical methods (Fig. 3).

4. Blood loss

Three articles were included [22,24,29], with 112 patients in the UBE group and 136 in the MD group. The heterogeneity analysis showed significant heterogeneity (I²=99%) and a random-effects model was used. Results showed that blood loss was significantly different, favoring the UBE surgery group (p=0.01; mean difference, −52.78; 95% CI, −93.47 to −12.08). A mean difference of −52.78 mL (95% CI, −93.47 to −12.08 mL; p=0.01) concluding that UBE surgery results in less bleeding than MD surgery was revealed using these data for meta-analysis (Fig. 4).

5. Area of dural sac expansion

Three articles were included, with 113 patients in the UBE group and 105 in the MD group [23–25]. The heterogeneity analysis showed that heterogeneity was not apparent (I²=0%) and the fixed-effects model was used. A mean difference of −1.27 (95% CI, −19.30, 16.77; p=0.89), suggesting that UBE surgery is similar in the degree of postoperative dural expansion to MD surgery, was shown using these data for meta-analysis (Fig. 5).

6. Postoperative complications

Eleven articles were included, with 449 patients in the UBE group and 521 in the MD group [15,21–30]. The heterogeneity analysis showed that heterogeneity was not obvious (I²=0%). The fixed-effects model was used. A mean difference of 0.76 in postoperative complications (95% CI, 0.47 to 1.22; p=0.26), suggesting that UBE surgery is similar in terms of postoperative complications to MD surgery, was shown using these data for meta-analysis (Fig. 6).

7. Hospital stay

Four articles were included, with 168 patients in the UBE group and 171 in the MD group [15,22,27,29]. The analysis of heterogeneity showed significant heterogeneity (I²=88%), and a random-effects model was used. A meta-analysis of these data revealed a mean difference of −3.06 days (95% CI, −3.84 to 2.28 days; p<0.01), concluding that the UBE operation has a shorter hospital stay than the MD operation (Fig. 7).

8. C-reactive protein changes 1 week after surgery

Two articles were included, with 65 patients in the UBE group and 60 in the MD group [24,28]. Significant heterogeneity was observed (I²=90%), and a random-effects model was used. A mean difference of −0.82 mg/L (95% CI, −2.08 to 0.43 mg/L; p=0.20), suggesting that UBE surgery is similar in terms of CRP value at 1 week after surgery to MD surgery, was shown using these data for meta-analysis (Fig. 8).

9. Visual Analog Scale score

Eight articles were included, with 597 patients in the UBE group and 586 in the MD group [15,22–26,28,29]. Both the overall and group heterogeneity analyses showed mild heterogeneity (I²≤50%), and the fixed-effects model was used. A meta-analysis of these data revealed a mean difference of −0.04 in the VAS score (95% CI, −0.14 to 0.06 score; p=0.47). There was no significant difference between the two groups in terms of VAS for leg pain at the end of follow-up (more than 12 months) (Fig. 9).

10. Oswestry Disability Index score

Seven articles were included, with 562 patients in the UBE group and 556 in the MD group [15,22–26,29]. Both the overall and group heterogeneity analyses showed that heterogeneity was not obvious (I²<50%) and the fixed-effects model was used. A meta-analysis of these data revealed a mean difference of −0.18 in the ODI score (95% CI, −0.76 to 0.40; p=0.54). There was no difference between the ODI score at the preoperative ODI and the ODI score at the last follow-up (more than 12 months) (Fig. 10).

11. The patient satisfaction (the modified MacNab score)

Only three articles were included, with 106 patients in the UBE group and 90 in the MD group [15,24,29]. The heterogeneity analysis showed that the heterogeneity was not obvious (I²=0%) and the fixed-effects model was used. A meta-analysis of these data revealed a mean difference of −0.18 (95% CI, −0.76 to 0.40; p=0.54). Thus, it was not possible to determine a difference in patient satisfaction based on the postoperative modified MacNab score between the two types of surgery (Fig. 11).

12. Publishing bias evaluation

The postoperative complications with the most included literature were selected for publication bias analysis, and a funnel chart was made. The 11 points in the figure were roughly symmetrically distributed, indicating that publication bias had a small effect on the results (Fig. 12).

Discussion

MD technology has always been the gold standard treatment for lumbar spinal stenosis [3,4]; however, it has certain limitations. It is limited in the scope of operation of the device and the field of view, which may lead to unsatisfactory decompression effects because this technique uses one incision. At the same time, the technology has a long learning curve, which makes it difficult for spinal surgeons to learn [5–10]. In recent years, the emerging UBE/BESS technology has used arthroscopic and conventional instruments. Through two channels, the instruments have the advantages of greater operating space and flexibility and a greater field of view. At the same time, it also has the advantages of less intraoperative bleeding and trauma; a smaller, shorter learning curve; increased safety and efficiency; and fewer complications. This technique has been applied to the treatment of lumbar spinal stenosis and has achieved satisfactory results [31–33].

From this study, there was no significant difference between the two surgical procedures in terms of operation time, postoperative dural expansion area, complications, or the modified MacNab score. The two surgical techniques included complications, preoperative VAS for leg pain and last follow-up (>12 months) VAS for leg pain, and preoperative ODI score and last follow-up (>12 months) ODI score, and there were no significant differences in any of the aspects. However, a subgroup analysis was carried out due to heterogeneity, and results showed no significant differences. This indicates that these two techniques may be equally applicable to the treatment of lumbar spinal stenosis, are safe and effective, and have similar clinical effects.

The spinal canal decompression extent can be studied using magnetic resonance imaging to measure the dural mater area after surgery. Two minimally invasive surgical techniques were used to treat lumbar spinal stenosis after sufficient decompression, and spinal canal stenosis was significantly enlarged. UBE technique was more flexible and the decompression was more thorough although there was no significant difference between the two, especially for patients with severe lumbar central canal stenosis [34]. Pao et al. [11] showed that the average increase in the cross-sectional dural area after the UBE technique was 105.9±39.5 mm², which corresponds to a preoperative increase of 201.9%±188.0%. Our comparison results also showed that the UBE technique has greatly improved after surgery. Research has shown that the technology has a short learning curve and can safely and effectively reduce pressure [11].

Serum creatine kinase (CK) and CRP have been used as parameters to assess muscle injury and acute inflammation, respectively. It was impossible to compare the two techniques in terms of surgical trauma due to the lack of postoperative CK data in this study. The results may have been affected by the large heterogeneity of the included studies although the results of this study showed that there were no significant differences in CRP 1 week after the operation. Choi and Kim [28] found that CK and CRP after the UBE technique were lower than those after the MD technique, indicating that the risk of muscle destruction and postoperative infection in UBE surgery was considerably smaller than that of the MD technique [24]. The UBE technique mainly causes less muscle damage through the intermuscular approach and the continuous saline can better flush the inflammatory debris.

The results of this study showed that the UBE technique has lower intraoperative blood loss and hospital stay than the MD technique. There were still significant differences between the two surgical techniques although the included studies were heterogeneous. The average length of hospital stay for patients treated with the UBE technique was 3.06 days shorter than that with the MD technique, likely due to UBE’s ability to minimize tissue damage and reduce operative muscle and ligament damage, intraoperative blood loss, and postoperative back pain recovery time [15,22]. This indicates that UBE technology may have some advantages over MD technology and patients undergoing UBE surgery may return to daily activities earlier. The stability of the spine is one of the factors that affects the patient’s early activities in the ground. Studies have shown that UBE technology causes minimal damage to the soft tissues and facet joints behind the spine. It can also safely and effectively decompress lumbar spinal stenosis and maintain segmental stability [11,35]. Pao et al. [11] showed that after adequate decompression of lumbar spinal stenosis treated with UBE technology, the contralateral facet joint preservation rate was 92.9% and that of the approach side was 84.2%. This may be another advantage of this technology.

This study has some limitations that need to be acknowledged. First, the best evidence for a systematic review is a randomized controlled trial. However, this systematic review only included two randomized controlled trials and the remaining nine were retrospective controlled studies, which may have distorted the results due to selection and recall bias. Second, the few included studies and the inconsistency of the results of the included studies indicate a high degree of variability in the results. Third, in the data included in this study for comparison, only the intraoperative blood loss and hospital stay were significantly different, and the heterogeneity showed obvious heterogeneity, which may be related to factors that depend on the operation situation and other variables. Further studies should be conducted with the same baseline and a larger sample size. The results of this study still have practical guiding significance despite the limitations.

Conclusions

There were no significant differences in the efficacy or safety of UBE and MD technology in the treatment of patients with lumbar spinal stenosis. However, UBE technology has less intraoperative bleeding and a shorter hospital stay. It can be well applied to lumbar spinal stenosis. It has a slight advantage and is a better surgical option than MD technology. More randomized controlled studies are needed to strengthen the current findings due to the inclusion of fewer studies.

Notes

Conflict of Interest

No potential conflict of interest relevant to this article was reported.

Funding

This study was supported by the National Natural Science Foundation of China (No. 81760231; No. 81160220); Natural Science Foundation of Ningxia Hui Autonomous Region (CN) (No. NZ17153; No. NZ11197); First-Class Discipline Construction Founded Project of NingXia Medical University and the School of Clinical Medicine (NXYLXK2017A05); and Natural Science Foundation of Ningxia Hui Autonomous Region (No. 2022AAC03398).

Author Contributions

Conception and design: Li Junjie, Yuan Haifeng; data acquisition: Li Junjie, Yin Jiheng, Liu Jun; analysis of data: Li Junjie, Yin Jiheng, Liu Jun; drafting of the manuscript: Li Junjie; critical revision: Li Junjie, Yin Jiheng, Liu Jun, Yuan Haifeng; obtaining funding: Lin haixiong, Yuan Haifeng; administrative support: Lin haixiong, Yuan Haifeng; and supervision: Yuan Haifeng.

Fig. 1

PRISMA (Preferred Reporting Items for Systematic reviews and Meta-Analyses) flow chart for the study search.

Fig. 2

Judgement of the risk of bias included in the randomized controlled trial (RCT). (A) RCT risk of bias graph. (B) Risk of bias summary.

Fig. 3

Forest plot of operation times for unilateral biportal endoscopy (UBE) vs. microscopic decompression (MD). SD, standard deviation; IV, inverse variance; CI, confidence interval; df, degrees of freedom.

Fig. 4

Forest plot of estimated blood loss for unilateral biportal endoscopy (UBE) vs. microscopic decompression (MD). SD, standard deviation; IV, inverse variance; CI, confidence interval; df, degrees of freedom.

Fig. 5

Forest plot of the area of dural sac expansion for unilateral biportal endoscopy (UBE) vs. microscopic decompression (MD). SD, standard deviation; IV, inverse variance; CI, confidence interval; df, degrees of freedom.

Fig. 6

Forest plot of complications associated with unilateral biportal endoscopy (UBE) vs. microscopic decompression (MD). M-H, Mantel–Haenszel; CI, confidence interval; df, degrees of freedom.

Fig. 7

Forest plot of lengths of hospital stay for unilateral biportal endoscopy (UBE) vs. microscopic decompression (MD). SD, standard deviation; IV, inverse variance; CI, confidence interval; df, degrees of freedom.

Fig. 8

Forest plot of CRP for the unilateral biportal endoscopy (UBE) vs. microscopic decompression (MD). SD, standard deviation; IV, inverse variance; CI, confidence interval; df, degrees of freedom.

Fig. 9

Subgroup analysis forest plot of preoperative and postoperative end of follow-up (more than 12 months) Visual Analog Scale (VAS) for leg pain for the unilateral biportal endoscopy (UBE) vs. microscopic decompression (MD). SD, standard deviation; IV, inverse variance; CI, confidence interval; df, degrees of freedom.

Fig. 10

Subgroup analysis forest plot of preoperative and postoperative end of follow-up (more than 12 months) Oswestry Disability Index (ODI) scores for unilateral biportal endoscopy (UBE) vs. microscopic decompression (MD). SD, standard deviation; IV, inverse variance; CI, confidence interval; df, degrees of freedom.

Fig. 11

Forest plot of patient satisfaction (the modified MacNab score) for unilateral biportal endoscopy (UBE) vs. microscopic decompression (MD). M-H, Mantel–Haenszel; CI, confidence interval; df, degrees of freedom.

Fig. 12

Funnel diagram of complications in the two surgical methods. OR, odds ratio; SE, standard error.

Table 1

Characteristics of included studies

Study	Design	Country	No. of patients (UBE/MD)	Age (yr) (UBE/MD)	Sex (M:F), (UBE/MD)	No. of levels	Complications	Outcomes	Final follow-up (mo)
Min et al. [15] (2020)	Case control study	Korea	54/35	65.74±10.52/66.74±7.96	27:27/19:16	All single level	UBE: dural tear (n=2), postoperative epidural hematoma (n=1); MD: dural tear (n=1), postoperative epidural hematoma (n=1)	VAS for back and leg; ODI; operative time; modified Macnab criteria; complication	UBE: 27.2±5.4 MD: 31.5±7.3
Ito et al. [21] (2021)	Single-center, retrospective analysis	Japan	42/139	66.3±12.3/65.0±11.1	28:14/71:68	All single level	UBE: dural injury (n=2); MD: hematoma (n=5), dural injury (n=8), reoperation (n=2)	VAS for back and leg; ODI; operative time; bone resection area; facet; preservation rates; EQ-5D questionnaire; complication	UBE: 6.7±0.6 MD: 6.9±0.8
Kim et al. [22] (2018)	Multicenter, retrospective analysis	Korea	60/81	46.60±14.18/54.22±20.21	37:23/24:57	All single level	UBE: change the surgical plan (n=3); MD: cerebrospinal fluid leakage (n=1), cerebrospinal fluid leakage and infection (n=1)	VAS for back and leg; ODI; operative time; complication; estimated blood loss; hospital stay; MacNab score; complications	UBE: 12.60±1.03 MD: 12.84±1.30
Heo et al. [23] (2019)	Retrospective analysis of prospectively	Korea	37/33	66.7±9.4/63.4±11.1	15:22/12:21	All single level	UBE: durotomy (n=1), postoperative hematoma (n=1) MD: durotomy (n=2), transient weakness (n=1), postoperative hematoma (n=2)	VAS for back and leg; ODI; operative time; dura expansion; angle of facetecomy; complication	UBE: 12.5±3.3 MD: 12.5±3.3
Kim et al. [24] (2020)	Retrospective study	Korea	30/30	64.23±5.26/66.20±6.01	13:17/12:18	All single level	UBE: cerebrospinal fluid leak (n=1); MD: cerebrospinal fluid leak (n=2), surgical site infection (n=1)	VAS; ODI; operative time; dura expansion; estimated blood loss; serum creatine kinase; CRP; modified MacNab score; complication	UBE: 12 MD: 12
Heo et al. [25] (2018)	A case control prospective study	Korea	46/42	65.8±8.9/63.6±10.5	18:28/16:26	All single level	UBE: durotomy (n=1), postoperative hematoma (n=1); MD: durotomy (n=1), postoperative hematoma (n=2)	VAS for back and leg; ODI; operative time; cross-sectional area of the dura; complication	UBE: 14.5±2.3 MD: 14.5±2.3
Park et al. [26] (2020)	Randomized controlled trial	Korea	32/32	66.2 (41–80)/ 67.1 (45–79)	13 :19/18 :14	All single level	UBE: incidental durotomy (n=2), postoperative epidural hematoma (n=1); MD: incidental durotomy (n=2), postoperative epidural hematoma (n=1), revision surgery due to recurrent pain (n=1)	VAS for back and leg; ODI; operative time; complication; EQ-5D score; hospital stay; postoperative drainage; serum creatine phosphokinase	UBE: 12 MD: 12
Kang et al. [27] (2019)	A prospective randomized comparative study	Korea	32/30	65.1±8.6/67.2±9.5	18:14/14:16	All single level	UBE: revision (n=1); MD: revision (n=1)	Operative time; hospital stay; Hemovac drain output; complication	UBE: 6 MD: 6
Choi et al. [28] (2019)	Retrospective study	Korea	35/30	65.4±11.8/65.2±12.0	14:21/17:13	UBE: single level (24), multiple levels (11); MD: single level (15), multiple level (15)	UBE: dural tear (n=2), root injury (n=1); MD: dural tear (n=2)	VAS for back and leg; ODI; CRP; complication; postoperative hemoglobin; transfusion	UBE: 6 MD: 6
Tuo et al. [29] (2021)	Retrospective analyzed	China	22/25	59.1±11.7/58.3±8.7	12:10/11:14	All single level	UBE: postoperative epidural hematoma (n=1), dura tear (n=3) MD: postoperative epidural hematoma (n=1), dura tear (n=5)	VAS; ODI; operative time; hospital stay; intraoperative blood loss; complication; modified MacNab criteria	UBE: 12 MD: 12
Lee et al. [30] (2020)	Retrospective	Korea	59/44	69.64±11.05/69.11±8.58	30:29/16:28	All single level	UBE: dura tear (n=6), infection (n=2), postoperative epidural hematoma (n=1), incomplete decompression (n=2), others (n=1); MD: dura tear (n=4), infection (n=2), postoperative epidural hematoma (n=1), others (n=1)	VAS for back and leg; ODI; operative time; drainage volume; hospital stay; complication	UBE: 3 MD: 3

Values are presented as number, mean±standard deviation, or mean (range), otherwise stated.

UBE, unilateral biportal endoscopy; MD, microscopic decompression; M, male; F, female; VAS, Visual Analog Scale; ODI, Oswestry Disability Index; EQ-5D, European Quality of Life-5 Dimensions; CRP, C-reactive protein.

Table 2

Quality evaluation according to the Risk of Bias Assessment of Non-randomized Studies Scale

Study	Selection of participants	Confounding variables	Measurement of exposure	Blinding of outcome assessment	Incomplete outcome data	Selective reporting outcome
Min et al. [15] (2020)	Low risk	Unclear risk	Low risk	High risk	Low risk	Low risk
Ito et al. [21] (2021)	Low risk	Low risk	Low risk	High risk	Low risk	Low risk
Kim et al. [22] (2018)	Low risk	Low risk	Low risk	High risk	Low risk	Low risk
Heo et al. [23] (2019)	Low risk	High risk	Unclear risk	High risk	Low risk	Low risk
Lee et al. [30] (2020)	Low risk	Unclear risk	Low risk	High risk	Low risk	Low risk
Choi et al. [28] (2019)	Low risk	High risk	Unclear risk	High risk	Low risk	Low risk
Tuo et al. [29] (2021)	Low risk	Low risk	Low risk	High risk	Low risk	Low risk
Kim et al. [24] (2020)	Low risk	High risk	Low risk	High risk	Low risk	Low risk
Heo et al. [25] (2018)	Low risk	Low risk	Low risk	High risk	Low risk	Low risk

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