1. Buckwalter JA. Aging and degeneration of the human intervertebral disc. Spine (Phila Pa 1976) 1995 20:1307–1314. PMID:
7660243.
2. Burke JG, Watson RW, McCormack D, Dowling FE, Walsh MG, Fitzpatrick JM. Intervertebral discs which cause low back pain secrete high levels of proinflammatory mediators. J Bone Joint Surg Br 2002 84:196–201. PMID:
11924650.
3. Moore RJ. The vertebral end-plate: what do we know? Eur Spine J 2000 9:92–96. PMID:
10823423.
4. Neidlinger-Wilke C, Wurtz K, Urban JP, et al. Regulation of gene expression in intervertebral disc cells by low and high hydrostatic pressure. Eur Spine J 2006 15(Suppl 3): S372–S378. PMID:
16680448.
5. Schroeder M, Viezens L, Schaefer C, et al. Chemokine profile of disc degeneration with acute or chronic pain. J Neurosurg Spine 2013 18:496–503. PMID:
23473344.
6. Aoki Y, Rydevik B, Kikuchi S, Olmarker K. Local application of disc-related cytokines on spinal nerve roots. Spine (Phila Pa 1976) 2002 27:1614–1617. PMID:
12163720.
7. Igarashi T, Kikuchi S, Shubayev V, Myers RR. 2000 Volvo Award winner in basic science studies: exogenous tumor necrosis factor-alpha mimics nucleus pulposus-induced neuropathology. Molecular, histologic, and behavioral comparisons in rats. Spine (Phila Pa 1976) 2000 25:2975–2980. PMID:
11145807.
8. Freemont AJ, Peacock TE, Goupille P, Hoyland JA, O'Brien J, Jayson MI. Nerve ingrowth into diseased intervertebral disc in chronic back pain. Lancet 1997 350:178–181. PMID:
9250186.
9. Lee S, Moon CS, Sul D, et al. Comparison of growth factor and cytokine expression in patients with degenerated disc disease and herniated nucleus pulposus. Clin Biochem 2009 42:1504–1511. PMID:
19563795.
10. Kepler CK, Markova DZ, Dibra F, et al. Expression and relationship of proinflammatory chemokine RANTES/CCL5 and cytokine IL-1β in painful human intervertebral discs. Spine (Phila Pa 1976) 2013 38:873–880. PMID:
23660804.
11. Weiler C, Nerlich AG, Bachmeier BE, Boos N. Expression and distribution of tumor necrosis factor alpha in human lumbar intervertebral discs: a study in surgical specimen and autopsy controls. Spine (Phila Pa 1976) 2005 30:44–53. PMID:
15626980.
12. Pfirrmann CW, Metzdorf A, Zanetti M, Hodler J, Boos N. Magnetic resonance classification of lumbar intervertebral disc degeneration. Spine (Phila Pa 1976) 2001 26:1873–1878. PMID:
11568697.
13. Olmarker K. Radicular pain: recent pathophysiologic concepts and therapeutic implications. Schmerz 2001 15:425–429. PMID:
11793146.
14. Specchia N, Pagnotta A, Toesca A, Greco F. Cytokines and growth factors in the protruded intervertebral disc of the lumbar spine. Eur Spine J 2002 11:145–151. PMID:
11956921.
15. Grang L, Gaudin P, Trocme C, Phelip X, Morel F, Juvin R. Intervertebral disk degeneration and herniation: the role of metalloproteinases and cytokines. Joint Bone Spine 2001 68:547–553. PMID:
11808997.
16. Gruber HE, Hanley EN Jr. Recent advances in disc cell biology. Spine (Phila Pa 1976) 2003 28:186–193. PMID:
12544938.
17. Abe H, Sakai T, Ando W, et al. Synovial joint fluid cytokine levels in hip disease. Rheumatology (Oxford) 2014 53:165–172. PMID:
24136066.
18. Orita S, Koshi T, Mitsuka T, et al. Associations between proinflammatory cytokines in the synovial fluid and radiographic grading and pain-related scores in 47 consecutive patients with osteoarthritis of the knee. BMC Musculoskelet Disord 2011 12:144PMID:
21714933.
19. Masuda K, An HS. Growth factors and the intervertebral disc. Spine J 2004 4(6 Suppl): 330S–340S. PMID:
15541686.
20. Freemont AJ, Watkins A, Le Maitre C, et al. Nerve growth factor expression and innervation of the painful intervertebral disc. J Pathol 2002 197:286–292. PMID:
12115873.
21. Yamauchi K, Inoue G, Koshi T, et al. Nerve growth factor of cultured medium extracted from human degenerative nucleus pulposus promotes sensory nerve growth and induces substance p in vitro. Spine (Phila Pa 1976) 2009 34:2263–2269. PMID:
19934806.
22. Olmarker K, Larsson K. Tumor necrosis factor alpha and nucleus-pulposus-induced nerve root injury. Spine (Phila Pa 1976) 1998 23:2538–2544. PMID:
9854752.