Low Back Pain: Current Surgical Approaches

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Abstract

Introduction

Low back pain (LBP) is a worldwide phenomenon. In the USA, back pain is the most common cause of activity limitation in people younger than 45 years, the second most frequent reason for visits to the family doctor, the fifth-ranking cause of admission to hospital, and the third most common cause of surgical procedures [123]. The UK studies place LBP as the largest single cause of absence from work, being responsible for about 12.5% of all sick days [4].

It is estimated that 75% to 80% of the adult population will experience LBP at least once in their lifetime [56789]. Most of these individuals do not seek medical care and are not disabled by their pain; instead, they recover spontaneously after a short period of time. However, around 10% of these patients go on to develop chronic persistent or recurrent pain [61011].

There are many parameters mentioned in the literature characterizing the symptoms of chronic LBP (CLBP); thus, it is very difficult to categorise these patients when reviewing the literature and formulating a management plan [12].

One good definition of CLBP is lumbar, sacral, or lumbosacral spinal pain that is continuous for 12 weeks or essentially continuous due to low-level pain punctuated by exacerbations of pain, each of which is characterized as acute [1314].

This review outlines the basics of the traditional approach to spinal surgery for CLBP secondary to degenerative disc disease (DDD) and osteoarthritis of the lumbar spine as well as explains the novel concepts and terminology of back pain surgery.

Aetiology

The most important causes of back pain can be classified into four main types as summarised in Table 1.

Table 1

Summary of the most common causes of lumbar back pain

A thorough history and physical examination are important to evaluate all possible factors contributing to the patient's pain and to assess its impact on the patient's functional ability [8]. The goal of medical evaluation is to efficiently identify the rare, serious causes (neoplasia, infection, inflammatory arthritis, and fracture) of LBP and to identify patients who may be at risk of delayed improvement due to neurologic impairment or psychosocial factors [10].

In patients without radicular symptoms or any red flags (e.g., inflammatory arthritis, infection, fracture, cancer, and cauda equina syndrome), a focused physical examination is usually sufficient [7]. In patients suspected of having a systemic or visceral cause of LBP, the physical examination must be expanded to include all organ systems [7].

Once other causes of back pain have been excluded and magnetic resonance imaging (MRI) scan (the gold standard investigation in back pain) confirms the presence of degenerated intervertebral discs, pain can be attributed to DDD. This is also known as discogenic back pain.

Disc degeneration, although in many cases asymptomatic, is strongly associated with back pain [15], Other clinical features of disc degeneration include disc herniation or prolapse. This is the main cause of sciatica and radicular pain (leg pain due to irritation of a nerve root in the spine) [16].

Discs degenerate far earlier than other musculoskeletal tissues; the first unequivocal findings of degeneration in the lumbar discs are seen in the age group 11 to 16 years [17]. About 20% of people in their teens have discs with mild signs of degeneration; degeneration increases steeply with age, particularly in males, so that around 10% of 50-year-old discs and 60% of 70-year-old discs are severely degenerated [18].

In general terms, DDD alters disc height and the mechanics of the spinal column; adversely affecting the behaviour of other spinal structures such as muscles and ligaments (Fig. 1). In the long-term, it can lead to spinal stenosis, a major cause of pain and disability in the elderly. Its incidence is rising exponentially with current demographic changes and an increased aged population.

Fig. 1

In the normal spine, the discs have high water content (left). As the disc degenerates, it dehydrates, losing height or collapse (right). This puts pressure on the facet joints and may result in arthritis of these joints. Both diagrams show a spinal segment; two adjacent vertebrae with a pair of facet joints and the intervertebral disc.

Spinal stenosis occurs when the space around the spinal cord narrows. This puts pressure on the spinal cord and nerve roots, leading to radicular pain, paraesthesia and or weakness.

The diagnosis of psychogenic back pain can only be made once all organic causes of pain have been excluded. This includes both pathology in the spine itself and elsewhere (such as the abdomen or chest) that can cause referred pain in the back. A classic example of this is pancreatic pathology that is often felt as back pain.

The Treatment Ladder

In patients with chronic pain, complete eradication of pain is rarely achieved and is not the goal of most interventions. Rather, the goals of treatment, which often require an interdisciplinary program, are moderation of pain, increased function, and decreased healthcare utilisation [19].

Nonpharmacologic therapies, as part of an interdisciplinary program for chronic LBP can include physical modalities, exercise, education, transcutaneous electrical nerve stimulation, acupuncture, manipulation and injections. These are usually utilised as adjunctive therapies and do not necessarily substitute for pharmacotherapy [20]. Many programs also include cognitive-behavioural therapy. The majority of patients achieve satisfactory results from these conservative measures; needing no further invasive therapies.

Once conservative measures have failed and the patient continues to have life limiting back pain, surgical options are explored. A stepwise model with increasing use of invasive treatments is proposed below and it can be effective in the management of selected patients. The classic treatment ladder showed a large difference in terms of tissue dissection and length of recovery between simple discectomies and fusion procedures. Newer therapies including arthroplasty, non fusion stabilisation, and interspinous implants provide intermediate options as will be discussed (Fig. 2) [21].

Fig. 2

The classic versus new treatment ladder of back pain. Reprinted from Bertagnoli [21] with permission from North American Spine Society.

Who Should See a Spinal Surgeon?

Patients with red flag symptoms should be referred on an urgent basis. In addition, we feel that patients who have failed conservative management and have had persistent pain for more than 6 months or individuals with chronic back pain with significant (new) radicular symptoms should be considered for referral to a spinal surgeon on a routine basis.

Surgical Options for Back Pain

2. Non fusion stabilisation

This has been an evolving technology over the last 15 to 20 years and offers a potential alternative to traditional fusion. Many different systems exist, but essentially they all aim to use flexible materials to stabilise the spine. The first design was called the Graf ligament; the implants employed screws to attach an artificial 'ligament' to the spine. It was designed to limit flexion and less so extension of a specific spinal segment by locking the facet joints. Results from early studies were very promising with one paper showing Graf ligament stabilisation resulting in a higher satisfaction rate (93%) when compared to traditional fusion (78%) [22]. However, on a longer follow-up, the use of the Graf ligament was found to be associated with high revision rates with up to 41% of patients stating they would not have the operation again [2324].

Dynesys is a similar type of device that has several modifications from the original Graf ligament: it limits both flexion and extension and hence helps to unload the intervertebral disc. Problems associated with these devices include screw loosening and cut out in the osteopenic bone; hence, it is used with caution in the elderly and those with osteoporotic bone. Initial studies found that Dynesys was preferable to fusion for treatment of degenerative spondylolisthesis and stenosis [25]. However, results of longer term studies were less encouraging, showing that patients undergoing Dynesys stabilisation had a 28% chance of requiring revision surgery [2627]. Another study suggested that disc degeneration at the bridged and adjacent segments appears to continue despite Dynesys stabilisation [28]. More recent reports state that Dynesys stabilisation appears to be acceptable compared to fusion [293031].

Another approach to non fusion spinal stabilisation has been the use of interspinous stabilisation devices. These fill the interspinous space and are attached to the spine by bands or sutures. They act by limiting flexion and extension and are often used in mild segmental degeneration or instability after open spinal decompression. These stabilisation devices include the Wallis ligament, DIAM, and Coflex. These devices increase the stability of a spinal segment and can be used in an early stage of DDD when at least 50% of disc height is maintained or in situations when DDD is likely to progress significantly; post discectomy with massive herniations, recurrent discectomies or adjacent segment degeneration after fusion [32]. Unfortunately, studies have suggested that the Wallis Ligament cannot reliably prevent recurrent disc herniation [33]. The number of good quality randomised trials is low, and there are many recommendations for further studies [34].

Similarly, DIAM has shown promising results for back pain due to disc degeneration with improved pain in 78.9% of the cases for up to 4 years [35363738]. The first prospective controlled study comparing decompression with Coflex to decompression alone suggested that results in both groups are similar [3940].

The advantages of interspinous devices are that they have lower risk than pedicle screws (which can penetrate neural elements of the cord/cauda equina). Most studies concluded that the results are similar to those of fusion and decompression although they can work very well in selected cases (Fig. 3).

Fig. 3

A picture of interspinous spacer (SMS Q Spine) implanted between the spinous process of two lumbar vertebrae.

1) Total disc arthroplasty

Traditionally, the mainstay of surgical management of back pain has been fusion. However, fusion of a spinal segment may have detrimental effects on the normal physiological and biomechanical function of the rest of the spine [41]. Decreased segmental mobility could lead to increased stress on the neighbouring spine, which increases degeneration at these levels. This is known as 'adjacent level disease' [4243]. For this reason non fusion/motion preserving techniques have been developed.

▪ Key points of non fusion stabilisation

· Various devices are used to prevent further disc degeneration

· Unpredictable efficacy; some patients achieve much better results than others

· Average hospital stay of 2 to 4 days

· Patients must avoid heavy lifting for at least 6 weeks; but can return to desk based activities once the wound has healed

Total disc replacement (TDR) is one such technique and it was developed to avoid the problems of adjacent level disease by preserving motion at the level. Pain relief is thought to be due to a combination of excision of the painful disc and restoration or improvement of load transfer [4445]. Prostheses are mainly used in the treatment of early disc degeneration, prior to facet joint degeneration. The prosthesis is implanted via an anterior retroperitoneal approach. After complete discectomy, the disc space is prepared and the implant is tapped into place (Fig. 4).

Fig. 4

Radiographs of an L5-S1 total disc replacement and a photograph of the prosthesis. Reprinted image of the Freedom Lumbar Disc with permission from AxioMed Spine Co., Cleveland, OH, USA.

Trials of disc replacement indicate a lower morbidity, quicker recovery, and better clinical outcome in these patients at one year compared to fusion surgery. However, at two years, there is a less significant difference between the two groups [4647]. In vitro studies indicate reduction of degeneration of the adjacent spine, but this still needs to be evaluated in prospective long-term studies.

▪ Key points of TDR

· Allows movement to be preserved at the 'degenerated/arthritic' level

· May prevent 'adjacent segment disease', i.e., arthritis developing at the vertebral joint above

· Needs large exposure to front of the spine, and hence longer recovery and potentially higher risk of complications

· Hospital stay between 4 to 7 days

· Patients will need to be at least 6 weeks away from work, and they will need to avoid prolonged sitting and heavy lifting

2) Facet arthroplasty/facet replacement

Total facet arthroplasty (TFA) is an articulating joint prosthesis intended to restore normal motion and provide stabilisation of spinal segments through replacement of the facets and excised elements of the posterior lumbar spine following facetectomy (removal of the facet joints) and neural decompressive procedures. Implanted via an open posterior surgical approach, the prosthesis is fixed into the pedicles using bone cement and is intended to provide immediate alignment and stabilisation of the spinal segment, while maintaining motion (Fig. 5) [48].

Fig. 5

Schematic diagram of the total facet arthroplasty system. Reprinted with permission from Globus Medical Inc., Phoenixville, PA, USA.

In vitro biomechanical testing of one type of the TFA has shown that the kinematics of the spine is more akin to the intact spine than that of posterior fusion [49]. However, this technology is still in the embryonic stage; as yet no clinical outcome studies exist and no case reports of fatigue of the implant have been reported [49].

Lessons learnt from the development of other joint replacement techniques lead us to hypothesise that the variation in alignment and hence in biomechanical kinematics between individuals and even between spinal levels has to be appreciated to ensure the success of this technology.

▪ Key points of total facet arthroplasty (TFA)

· For the treatment of symptomatic 'facet joint arthritis'

· A relatively novel procedure; long-term results unknown

· Allows movement to be preserved

· Not widely performed

3) Fusion

Lumbar fusion is often used in the treatment of symptomatic lumbar DDD when conservative management has failed [50]. Results of lumbar fusion include 50% reduction in back and leg pain intensities as well as improvement in patient outcome scores and mental and physical Short Form-36 scores [51].

The logic behind surgery is that by fusing two vertebrae together, they will act and function as a solid bone. Since lumbar pain may be caused by excessive motion of the vertebra, the goal of spinal fusion surgery is to eliminate that extra motion in between the vertebrae, alleviating pain.

A variety of techniques have been developed for lumbar spinal fusion. Interbody fusion has become widely popular since it provides a large surface area for fusion with the graft under compression. Traditionally, this can be achieved via either anterior or posterior approaches. Anterior surgery or anterior lumbar interbody fusion (ALIF) involves access to the lumbar spine via the abdominal cavity, and hence it carries the risk of catastrophic bleeding from injury to major vessels as well as iatrogenic injury to viscera and associated structures. The posterior approach, posterior lumbar interbody fusion (PLIF) is more commonly used, as the associated spinal canal stenosis can also be addressed by canal decompression (Fig. 6).

Fig. 6

Approaches to lumbar spine can be broadly divided into anterior (red arrow) and posterior (blue arrow). Axial magnetic resonance imaging also demonstrating extreme lateral access (black arrow) and transforaminal (green arrow) approaches.

Another commonly used fusion technique, either in combination with PLIF or alone is posterolateral fusion. In this technique, a fusion mass is made using a bone graft between the transverse processes of adjacent vertebrae. This technique is supplemented with instrumentation, typically in the form of pedicle screws and rods to stabilise the segment; allowing fusion to occur between the two vertebrae (Fig. 7).

Fig. 7

Pedicle screws are inserted posteriorly through the pedicles into the vertebral body. Rods are used to stabilise the two vertebrae by linking them to the pedicle screws. If indicated, several levels can be fused at the same time.

No particular technique has yet been demonstrated to yield superior results [52], and hence the technique used is dependent on patient size and anatomy, deformity of the spine, and surgeon's preference.

▪ Key points of fusion

· Gold standard surgical treatment in the management of back pain

· Many different techniques and approaches; all aim to fuse arthritic/painful joint

· Hospital stay of 37 days

· Can initially worsen pain in the first 6 weeks

· No heavy lifting for 3 months, until bony fusion has occurred. This may be delayed in smokers

· Patient can return to desk based activities after 2 weeks or once pain reduces

4) Minimally invasive fusion

Open surgical approaches to fusion such as ALIF and PLIF are complex and often require muscular and ligamentous dissection, neural retraction, and mobilisation of vascular and visceral structures. Complications include vascular injury, sympathetic dysfunction, and bowel injuries [53]. Advances in minimally invasive spine surgery (MISS) have led to a number of alternative approaches, all designed to minimise morbidity and the complications associated with a traditional anterior surgical approach.

Established minimally invasive techniques include laparoscopic ALIF, minimally invasive PLIF, and these have been discussed extensively in the literature [545556].

More recent developments in MISS include the extreme lateral interbody fusion (XLIF) approaches, as well as transsacral fusion (axial lumbar interbody fusion, AxiaLIF). Less soft tissue dissection allows for early recovery and rehabilitation of the patient. It leads to less postoperative pain, reduced surgical time, and less blood loss [5758]. For the patient, this means less time in the hospital and a faster return to daily activities.

Extreme Lateral Interbody Fusion

This technique can be used to gain access to the lumbar spine via a lateral approach that passes through the retroperitoneal fat and psoas major muscle. Hence, the potential complications with an anterior transperitoneal approach to the lumbar spine can be avoided and major vessels are not encountered, the procedure can be done through two 3 to 4-cm incisions [53].

The XLIF approach allows for anterior access to the disc space without the complications of an anterior intra-abdominal procedure (Fig. 8).

Fig. 8

Schematic drawing showing the extreme lateral interbody fusion procedure; the retractor is inserted into the retroperitoneal space, penetrating the psoas muscle, and positioned directly on the lateral intervertebral disc space.

Published results of this technique are encouraging, 95% fusion rates at 6 months; 86.7% of patients reported satisfaction with their procedures at 1 year, 90.4% of patients electing to have the surgery again if needed. Compared with traditional open approaches, the XLIF technique has been shown to result in a lower incidence of infection, visceral and neurologic injury, and transfusion as well as markedly shorter hospitalization [5960].

There are several limitations to the XLIF approach. Access to the L5-S1 disc is not possible and the L4-5 disc level can be obstructed by a high iliac crest or aberrant lumbar plexus anatomy. Similarly, access to the L1-2 level can sometimes be hindered by lower ribs. Trauma to the lumbar plexus is a potentially disastrous complication that can occur if adequate caution is not exercised while dissecting through the psoas muscle. However, intraoperative neural monitoring is designed to detect the lumbar plexus at a safe distance before significant retraction and insertion of surgical instruments (Fig. 9) [59].

Fig. 9

Radiograph showing interbody fusion after the extreme lateral interbody fusion procedure supplemented by posterior instrumentation, which can also be achieved by minimally invasive spine surgery; useful in correcting the spinal deformity.

Axial Lumbar Interbody Fusion

The AxiaLIF system (TranS1 Inc., Wilmington, NC, USA) is based on the application of minimally invasive techniques to attain fusion at L5-S1 and L4-S1 levels utilising an axially placed lumbar device implanted via the presacral retroperitoneal tract. The presacral access route to the L5-S1 intervertebral space is a distinct surgical approach to lumbar interbody fusion. This atraumatic tissue plane alleviates the need for the surgeon to cut through paraspinal muscles and remove laminae and facet joints, potentially lessening postoperative patient pain and the likelihood of complications.

Biomechanical studies show the AxiaLIF rod provides more stability when compared with all other stand-alone interbody cages (Figs. 10, 11) [61].

Fig. 10

The axial interbody fusion rod is implanted into the L5-S1 disc space, making it a stable construct containing bone graft. Reprinted with permission from Surgi-C Ltd., Birmingham, UK.

Fig. 11

(A) Computer tomography image of the axial interbody fusion with the formation of a bridging callus between the sacrum and the L5 vertebra. (B) Schematic showing AxiaLIF Rod inserted between S1 and L5 vertebrae. Reprinted from Tobler et al. [62] with permission of Wolters Kluwer Health Inc.

Published case series of this technique show mean pain scores of over 60%. Two-year clinical success rates on the basis of change of at least 30% relative to baseline were 86% for pain and 74% for function. The overall radiographic fusion rate at 2 years was 94% [62].

The primary concern about AxiaLIF is safety; anatomic studies show a great variation in the anatomy increasing the chance of pelvic splanchnic nerve and lateral sacral vessel injury as well as rectal perforation [63].

In addition to this, revision surgery for pseudarthrosis (failure of fusion) with the AxiaLIF system poses a challenge. Traversing an already scarred presacral tract raises concerns of the previously mentioned complications [64].

Conclusions

Chronic lumbar back pain is common, and the majority of patients can be successfully managed by a combination of conservative approaches. A significant number of patients continue to have life limiting CLBP despite conservative measures. Once other causes of back pain have been ruled out by rigorous history, examination, and directed investigations, in most cases, CLBP can be attributed to DDD.

Traditionally, the stepwise approach to surgery starts with local and steroid injection leading to fusion. Fusion aims to alleviate pain by preventing movement between the two affected vertebrae. A fusion mass can be created between the transverse process in the 'posterolateral gutter' during posterior surgery or between vertebral bodies in the form of ALIF or PLIF.

Established MISS techniques include laparoscopic ALIF and MISS posterior instrumentation with pedicle screws and rods. Newer MISS techniques include XLIF and AxiaLIF. All of these techniques aim to reduce tissue dissection, blood loss and recovery time; however, they are heavily dependent on the X-ray and have their own set of complications.

No particular technique has yet been demonstrated to yield superior results [52], and hence the technique used is dependent on patient size and anatomy, deformity of the spine, and surgeon's preference.

The main problem of fusion is the disruption of the biomechanics and kinematics of the rest of the spine caused by a rigid segment; leading to adjacent level disease. Theoretically, this can be prevented by performing motion preserving surgeries such as TDR, facet arthroplasty, and non fusion stabilisation. However, this is yet to be demonstrated by adequate clinical data.

Pioneering research into the treatment of CLBP in the future involves a better understanding of disc physiology, pathology, and stem cell research into regeneration of human disc tissue. Disc cells have been grown in vitro; however, the translation of this research into clinical practice is probably still several years away [65].

In addition to this, there is particular interest in understanding of the way in which chronic pain is controlled and modulated. Functional MRI studies have shown that some patients can modulate chronic pain in a 'central' manner. In clinical practice, this means that despite elimination of peripheral pain sources, hard-wired central pathways can cause residual pain leading to unsuccessful surgery. This phenomenon is not confined to the spine, and it has been found to be the cause of failed hip and knee replacement as well as failed back surgery. It is hoped that a better understanding of who develops central pain pathways and when they develop these pathways will allow early intervention to prevent this phenomenon [66].

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